Members
Assistant Professor Hitoshi OHTANI
EMAIL: otani_at_agr.nagoya-u.ac.jp （please replace _at_ by @）
Education
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2005
B.Sc. Faculty of Human Science, Waseda University, Japan
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2007
M.Sc. Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
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2011
Ph.D. Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
Professional Experience
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2011-2014
Assistant Professor, Keio University School of Medicine, Japan
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2014-2020
Post-doc, Van Andel Research Institute, MI, USA
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2020-
Assistant Professor, Nagoya University, Japan
Major Publications before Joining the Lab
- Ohtani H, Liu M, Liang G, Jang HJ, Jones PA.
Efficient activation of hundreds of LTR12C elements reveals cis-regulatory function determined by distinct epigenetic mechanisms.
Nucleic Acids Res 52, 8205-8217 (2024) [Pubmed] - Ohtani H, Ørskov AD, Helbo AS, Gillberg L, Liu M, Zhou W, Ungerstedt J, Hellström-Lindberg E, Sun W, Liang G, Jones PA, Grønbæk K.
Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity are Linked to Clinical Responses to 5-Azacytidine.
Cancer Res 80, 2441-2450 (2020) [Pubmed] - Jones PA, Ohtani H, Chakravarthy A, Carvalho DD.
Epigenetic Therapy in Immune-Oncology.
Nat Rev Cancer 19, 151-161 (2019) [Pubmed] - Ohtani H, Liu M, Zhou W, Liang G, Jones PA.
Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses.
Genome Res 28, 1147-1157 (2018) [Pubmed] - Liu M#, Ohtani H#, Zhou W, Ørskov AD, Charlet J, Zhang YW, Shen H, Baylin SB, Liang G, Grønbæk K, Jones PA.
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.
Proc Natl Acad Sci USA.113,10238–10244 (2016) [Pubmed] - Ohtani H, Iwasaki YW, Shibuya A, Siomi H, Siomi MC, Saito K.
DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila Ovary.
Genes Dev 27, 1656-1661 (2013) [Pubmed] - Ohtani H, Naruse TK, Iwasaki Y, Ishida T, Akari H, Matano T, Kimura A.
Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates.
Immunogenet 64, 669-678 (2012) [Pubmed] - Ohtani H, Nakajima T, Akari H, Ishida T, Kimura A.
Molecular evolution of immunoglobulin superfamilygenes in primates.
Immunogenet 63, 417-428 (2011) [Pubmed]
